{"id":546,"date":"2025-02-21T09:39:33","date_gmt":"2025-02-21T09:39:33","guid":{"rendered":"https:\/\/cblc.mydonor.app\/projects\/"},"modified":"2026-02-01T08:34:29","modified_gmt":"2026-02-01T08:34:29","slug":"projects","status":"publish","type":"page","link":"https:\/\/cblc.mydonor.app\/en\/projects\/","title":{"rendered":"Projects"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” equal_height=”yes” content_placement=”middle” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”8%” bottom_padding=”5%” constrain_group_2=”yes” bottom_padding_tablet=”4%” left_padding_tablet=”6%” constrain_group_4=”yes” right_padding_tablet=”6%” left_padding_phone=”7vw” constrain_group_6=”yes” right_padding_phone=”7vw” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_element_direction_desktop=”default” column_element_spacing=”0px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”static” advanced_gradient_angle=”65″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”advanced” gradient_type=”advanced” advanced_gradient_display_type=”linear”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bottom_padding=”7%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”0px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” enable_animation=”true” animation=”fade-in” animation_easing=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default” animation_offset=”90%”][nectar_animated_shape shape_color=”#009aa9″ width_desktop=”15vw” width_tablet=”20vw” width_phone=”25vw” animation=”none” animation_easing=”default” animation_movement_type=”transform_y” animation_movement_intensity=”0.6″ animation_movement_persist_on_mobile=”true” position_desktop=”absolute” top_position_desktop=”0″ left_position_desktop=”0″ translate_y_desktop=”-30%” translate_x_desktop=”-50%” zindex=”-1″][nectar_highlighted_text scribble_color=”#009aa9″ style=”scribble” scribble_shape=”squiggle-underline” scribble_thickness=”thick” scribble_speed=”1.8s” scribble_easing=”ease_in_out” custom_font_size=”3vw” id=”circle-highlight2″ font_line_height=”1.4″ font_size_tablet=”5vw” font_size_phone=”7vw” text_direction=”default”]\n

Projects<\/em><\/h2>\n[\/nectar_highlighted_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” bottom_padding=”2%” constrain_group_2=”yes” bottom_padding_tablet=”4%” left_padding_tablet=”6%” constrain_group_4=”yes” right_padding_tablet=”6%” left_padding_phone=”7vw” constrain_group_6=”yes” right_padding_phone=”7vw” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_element_direction_desktop=”default” column_element_spacing=”0px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”static” advanced_gradient_angle=”65″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”advanced” gradient_type=”advanced” advanced_gradient_display_type=”linear”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text css=”” text_direction=”default”]The Association supports scientific research and every initiative aimed at improving the knowledge, diagnosis and treatment of methylmalonic acidemia with homocystinuria cblC.<\/p>\n

The Association aims also to safeguard the rights of patients, to promote their social integration and improve the quality of life of both patients and their families.<\/p>\n

The main projects supported by the Association are listed below:[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”4%” bottom_padding=”8%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_row_inner equal_height=”yes” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][fancy_box box_style=”default” icon_family=”none” image_url=”113″ color=”accent-color” border_radius=”5px” image_loading=”default” link_url=”https:\/\/cblc.mydonor.app\/progetti\/analisi-multiomica-dellalterazione-dellomeostasi-mitocondriale-autofagica-e-lisosomiale-nella-cblc\/” image_size=”large”]\n

Mitochondrial homeostasis in cblC<\/h3>\n

Multiomic analysis of altered mitochondrial, autophagic, and lysosomal homeostasis in cblC methylmalonic acidemia[\/fancy_box][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][fancy_box box_style=”default” icon_family=”none” image_url=”61″ color=”accent-color” border_radius=”5px” image_loading=”default” link_url=”https:\/\/cblc.mydonor.app\/progetti\/terapia-enzimatica-sostitutiva-ert-therapy\/” image_size=”large”]\n

ERT therapy<\/h3>\n

To demonstrate in vitro that this disease can be treated with protein replacement therapy (ERT) achieving restoration of normal metabolic pathways after treatment with a recombinant MMACHC protein.[\/fancy_box][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_content” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”0px” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”advanced” border_bottom_desktop=”1″ column_border_color=”#919ec6″ column_border_style=”solid”][vc_row_inner equal_height=”yes” column_margin=”none” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-5-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/3″ tablet_width_inherit=”default” animation_type=”default” enable_animation=”true” animation=”fade-in” animation_easing=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text css=”.vc_custom_1740478861022{margin-bottom: 30px !important;}” text_direction=”default”]\n

MMACHC in CBLC<\/h3>\n

Identification of compounds to rescue MMACHC functional deficiency in CBLC disease[\/vc_column_text][image_with_animation image_url=”59″ image_size=”medium” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”zoom-crop” alignment=”” img_link_large=”yes” border_radius=”none” box_shadow=”x_large_depth” image_loading=”default” max_width=”100%” max_width_mobile=”default”][divider line_type=”No Line” custom_height=”25″][nectar_btn size=”medium” open_new_tab=”true” button_style=”see-through” button_color_2=”Accent-Color” icon_family=”none” text=”More information” url=”https:\/\/mcusercontent.com\/f4df0c738edbf7df6565df2fe\/files\/15b7c260-c5f3-71d3-295b-d714c36e27d1\/2022_Cblc_Research_Grant_PR_Issued_5.13.2022_Final.pdf” aria_label_text=”Link di approfondimento MMACHC in CBLC”][\/vc_column_inner][vc_column_inner column_padding=”padding-5-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/3″ tablet_width_inherit=”default” animation_type=”default” enable_animation=”true” animation=”fade-in” animation_easing=”default” bg_image_animation=”none” border_type=”advanced” border_left_desktop=”1″ border_right_desktop=”1″ column_border_color=”#919ec6″ column_border_style=”solid” delay=”150″][vc_column_text css=”.vc_custom_1740478848497{margin-bottom: 30px !important;}” text_direction=”default”]\n

MMACHC knock-out in Medaka<\/h3>\n

Generation and characterization of a MMACHC model knock-out in Medaka[\/vc_column_text][image_with_animation image_url=”61″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”zoom-crop” alignment=”” img_link_large=”yes” border_radius=”none” box_shadow=”x_large_depth” image_loading=”default” max_width=”100%” max_width_mobile=”default”][divider line_type=”No Line” custom_height=”25″][nectar_btn size=”medium” button_style=”see-through” button_color_2=”Accent-Color” icon_family=”none” text=”More information” url=”https:\/\/cblc.mydonor.app\/progetti\/generazione-e-caratterizzazione-di-un-modello-di-mmachc-knock-out-in-medaka\/” aria_label_text=”progetto di generazione e caratterizzazione di un modello di mmachc knick out in medaka”][\/vc_column_inner][vc_column_inner column_padding=”padding-5-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/3″ tablet_width_inherit=”default” animation_type=”default” enable_animation=”true” animation=”fade-in” animation_easing=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” delay=”300″][vc_column_text css=”.vc_custom_1740479008584{margin-bottom: 30px !important;}” text_direction=”default”]\n

LC_MS\/MS System<\/h3>\n

Spettrometro Thermo Scientific Q Exactive Orbitrap LC_MS\/MS System[\/vc_column_text][image_with_animation image_url=”62″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”zoom-crop” alignment=”” img_link_large=”yes” border_radius=”none” box_shadow=”x_large_depth” image_loading=”default” max_width=”100%” max_width_mobile=”default”][divider line_type=”No Line” custom_height=”25″][nectar_btn size=”medium” button_style=”see-through” button_color_2=”Accent-Color” icon_family=”none” text=”More information” url=”https:\/\/cblc.mydonor.app\/progetti\/thermo-scientific-q-exactive-orbitrap-lc-ms-ms-system\/” aria_label_text=”progetto thermo scientific q exactive orbitrap lc ms ms system”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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